Advanced Analytical Technologies
In our center, the studies are mostly concentrated on the synthesis of bioactive compounds, nanomaterial synthesis and surface modifications, tissue engineering studies and biomaterial production, molecular biological mechanisms. Therefore, a wide range of analytical methods can be used in the purification and characterization of the intermediate or final products obtained from the above mentioned studies.
Our Ultraviolet-Visible (UV-Vis) spectrophotometer allows to examine properties such as absorbance and reflectance from solid and liquid samples at wavelengths between 185-3300 nm for spectroscopic analysis. Spectrofluorometer allows to examine the fluorescence properties of materials. Fourier Transform Infrared (FTIR) and Raman spectroscopes allow to obtain information about molecular bonds through vibrational spectroscopy. In addition, hydrodynamic diameter and zeta potential properties of nano-scale materials can be determined by means of photon correlation spectroscopy in Dynamic Light Scattering (DLS) device.
Chromatography and mass spectrometry method which is conjugated to chromatography, are used in the purification of active pharmaceutical ingredients from natural products, purification and characterization of the final product after biological and chemical synthesis. For this purpose, HPLC, LC-MS, GC-MS and also FPLC, which is an effective system for protein and oligonucleotide purification, are used. The MALDI-TOF/TOF mass spectrometer, which is important in molecular biology and genetics studies, is also used for species determination studies in bacteria and for determination of molecular weights of organic-inorganic molecules. For sensitive elemental analysis, a four quadrupole ICP-MS system is used.
Three-dimensional structures of chemical and biological molecules are determined with the Single-crystal XRD instrument, which is an extremely important achievement for our center and our country in the context of structural biology studies. Moreover, with a system integrated into the device, which will make significant contributions to drug R&D studies, the interactions of drug candidate molecules with the target protein/enzyme can be determined with high efficiency.
In addition to these systems, Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) systems are used for material structure analysis and impurity control. Optical tensiometry system is used to determine the liquid and solid properties such as wettability, liquid absorption, liquid dispersion, surface heterogeneity, emulsion stability.